SÍNTESIS QUIRAL DE N-(3,4-DIFLUORO-2-[(2-FLUORO-4-YODOFENIL)AMINO]-6-METOXIFENIL}- 1-[2,3-DIHIDROXI-PROPIL]CICLOPROPANOSULFONAMIDAS

LA PRESENTE INVENCIÓN SE REFIERE A UN NOVEDOSO MÉTODO ENANTIOSELECTIVO PARA PREPARAR ENANTIÓMEROS (S)- Y (R)- DE N-{3,4-DIFLUORO-2-[(2-FLUORO-4-YODOFENIL)AMINO]-6-5-METOXIFENIL}-1-[2,3-DIHIDROXI-PROPIL]CICLOPROPANOSULFONAMIDA, A COMPUESTOS INTERMEDIARIOS NOVEDOSOS, Y AL USO DE DICHOS COMPUESTOS INTE...

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Bibliographic Details
Main Authors FEY, PETER, MAYER, AGATHE, CHRISTINE
Format Patent
LanguageSpanish
Published 13.11.2014
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:LA PRESENTE INVENCIÓN SE REFIERE A UN NOVEDOSO MÉTODO ENANTIOSELECTIVO PARA PREPARAR ENANTIÓMEROS (S)- Y (R)- DE N-{3,4-DIFLUORO-2-[(2-FLUORO-4-YODOFENIL)AMINO]-6-5-METOXIFENIL}-1-[2,3-DIHIDROXI-PROPIL]CICLOPROPANOSULFONAMIDA, A COMPUESTOS INTERMEDIARIOS NOVEDOSOS, Y AL USO DE DICHOS COMPUESTOS INTERMEDIARIOS NOVEDOSOS PARA LA PREPARACIÓN DE DICHOS COMPUESTOS INTERMEDIARIOS NOVEDOSOS PARA LA PREPARACIÓN DE DICHOS ENANTIÓMEROS ARRIBA MENCIONADOS The present invention relates to a novel enantioselective method of preparing (S)- and (R)-enantiomers of N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-5 methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamide, to novel intermediate compounds, and to the use of said novel intermediate compounds for the preparation of said (S)- and (R)-enantiomers of N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamide.
Bibliography:Application Number: GT20130000294