AGONISTAS DE PPARA/Y Y PROCESOS DE PREPARACIÓN

• Main Authors: PRASAD KOTESWARA KAPA, ADA SKORODINSKY, CHRISTINE E. GARRETT, GEORGE TIEN-SAN LEE, MICHAEL J. GIRGIS, JAMES ANTHONY VIVELO, PIOTR KARPINSKI, GUANG-PEI CHEN, DIMITRIS PAPOUTSAKIS, XINGLONG JIANG, BEATA SWERYDAKRAWIEC
• Format: Patent
• Language: Spanish
• Published: 19.03.2007
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

LA PRESENTE INVENCIÓN PROPORCIONA UN MÉTODO PARA LA PREPARACIÓN DE COMPUESTOS QUE TIENEN LA ESTRUCTURA I, QUE SON AGONISTAS DEL RECEPTOR ACTIVADO POR LOS PROLIFERADORES DE PEROXISOMA (PPAR) ALFA Y GAMMA. DE UNA MANERA MÁS ESPECÍFICA LA INVENCIÓN SE REFIERE A UN NUEVO PROCESO PARA LA PREPARACIÓN DEL ÁCIDO (2R)-2,3-DIHIDRO-1-[[4-[5-METIL-2-[4-(TRIFLUORO-METIL)-FENIL]-4-OXAZOLIL]-METOXI]-FENIL]-SULFONIL] This invention provides a method for preparing compounds having the structure [Formula (I)] wherein L is [Formula (A)] or [Formula (B)] in which R1 is hydrogen or optionally substituted alkyl, n is zero or 1 and m is 1; wherein R is H, halogen, optionally substituted C1-6alkyl or C1-6alkoxy; wherein Z is a bond, O or S; wherein p is an integer from 1 to 5; wherein Q is a bond provided that Z is not a bond when p is 1; or Q is O, S or -C(O)NR6- in which R6 is hydrogen, optionally substituted alkyl or cycloalkyl; or Q is -NR6-, -NR5C(O)NH- or -NR5C(O)O- in which R5 is hydrogen, alkyl or aralkyl provided that p is not 1; wherein W is cycloalkyl, aryl or heterocyclyl; or W and R6 form a 9- to 10-membered bicyclic ring, which may be optionally substituted or may contain oxygen, nitrogen or sulfur.