PROCEDIMIENTO PARA LA PREPARACION DE UNA COMPOSICION FARMACEUTICA SOLIDA ADMINISTRABLE ORALMENTE

LA PRESENTE INVENCION SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION DE UNA COMPOSICION FARMACEUTICA SOLIDA ADMINISTRABLE ORALMENTE QUE CONTIENE 5CLORON({(5S)2OXO3[4(3OXO4MORFOLINIL)FENIL]1,3OXAZOLIDIN5IL}METIL)2TIOFENCARBOXAMIDA LA CUAL ES DE UTILIDAD EN LA PROFILAXIS Y/O TRATAMIENTO DE DISTINTA...

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Bibliographic Details
Main Author KLAUS BENKE
Format Patent
LanguageSpanish
Published 12.07.2005
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:LA PRESENTE INVENCION SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION DE UNA COMPOSICION FARMACEUTICA SOLIDA ADMINISTRABLE ORALMENTE QUE CONTIENE 5CLORON({(5S)2OXO3[4(3OXO4MORFOLINIL)FENIL]1,3OXAZOLIDIN5IL}METIL)2TIOFENCARBOXAMIDA LA CUAL ES DE UTILIDAD EN LA PROFILAXIS Y/O TRATAMIENTO DE DISTINTAS ENFERMEDADES TROBOEMBOLICAS. Production of solid, orally administered pharmaceutical compositions (A) containing 5-chloro-N-(((5S)-2-oxo-3-(4-(3-oxo-4-morpholinyl)-phenyl)-1,3-oxazolidin-5-yl)-methyl)-2-thiophene-carboxamide (I) in hydrophilized form comprises: (a) preparing granules containing (I) in hydrophilized form by wet granulation; and (b) converting the granules, optionally with suitable additives, into (A). Independent claims are included for: (1) the compositions (A) obtained by the process; and (2) solid, orally administered pharmaceutical compositions (A') containing (I) in hydrophilized form in general. ACTIVITY : Thrombolytic; Anticoagulant; Cardiant; Antianginal; Vasotropic; Cerebroprotective. MECHANISM OF ACTION : Coagulation factor Xa inhibitor.
Bibliography:Application Number: GT20040000239