COMPUESTOS Y COMPOSICIONES FARMACEUTICAS Y METODOS PARA INHIBIR KINASAS PROTEINICAS

• Main Authors: SIEGFRIED HEINZ REICH, MICHAEL B. WALLACE
• Format: Patent
• Language: Spanish
• Published: 14.03.2002
• Edition: 6
• Subjects: BLASTING; BURNERS; CHEMISTRY; COMBUSTION APPARATUS; COMBUSTION PROCESSES; HEATING; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; LIGHTING; MECHANICAL ENGINEERING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; WEAPONS

COMPUESTOS DE AMINOPIRAZOL QUE MODULAN Y/O INHIBEN LA ACTIVIDAD DE KINASAS PROTEINICAS. ESTOS COMPUESTOS Y LAS COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN SON CAPACES DE MEDIAR Y/O INHIBIR LA ACTIVIDAD DE KINASAS DEPENDIENTES DE LA CICLINA, POR TANTO MODULANDO Y/O INHIBIENDO LA PROLIFERACION CELULAR INDESEADA. EL INVENTO ESTA TAMBIEN DIRIGIDO AL USO TERAPEUTICO O PROFILACTICO DE COMPOSICIONES FARMACEUTICAS QUE CONTIENEN TALES COMPUESTOS Y A METODOS DE TRATAMIENTO DE CANCER ADEMAS DE OTROS ESTADOS DE ENFERMEDAD ASOCIADOS CON ANGIOGENESIS INDESEADA Y/O PROLIFERACION CELULAR, TAL COMO RETINOPATIIA DIABETICA, GLAUCOMA NEUROVASCULAR, ARTRITIS REUMATICA Y SORIASIS, ADMINISTRANDO CANTIDADES EFICACES DE TALES COMPUESTOS. Amino-pyrazole compounds that modulate and/or inhibit the activity of protein kinases. These compounds and pharmaceutical compositions containing them are capable of mediating and/or inhibiting the activity cyclin-dependent kinases, thereby modulating and/or inhibiting unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.