PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREFOR

Η εφεύρεση αναφέρεται σε νέα βελτιωμένη μεθοδο παρασκευής της 8-{4-ω The invention relates to a new and improved process for the preparation of 8-{4-[4-(2-pyrimidinyl)--1- piperazinyl]-butyl}-8-aza-spiro[4.5]decane-7,9--dione of the Formula I < IMAGE > and pharmaceutically acceptable acid addi...

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Bibliographic Details
Main Authors MEZEI TIBOR DR, REITER (NEE) ESSES KLARA DR, TAJTHY (NEE) JUHASZ EVA JUDIT, GREGOR (NEE) BOROS LIVIA, BUDAI ZOLTAN DR
Format Patent
LanguageEnglish
Greek
Published 16.12.1988
Edition4
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Η εφεύρεση αναφέρεται σε νέα βελτιωμένη μεθοδο παρασκευής της 8-{4-ω The invention relates to a new and improved process for the preparation of 8-{4-[4-(2-pyrimidinyl)--1- piperazinyl]-butyl}-8-aza-spiro[4.5]decane-7,9--dione of the Formula I < IMAGE > and pharmaceutically acceptable acid addition salts thereof, which comprises hydrogenating a compound of the general Formula II < IMAGE > (wherein A stands for -C IDENTICAL C- or CH=CH-) and, if desired, converting the compound of the Formula I thus obtained into a pharmaceuticaily acceptable acid additfon salt thereof. The compound of the Formula I is a known anxioselective agent. The invention also relates to intermediates of Formula II used in the above process and a method for the preparation thereof. These compounds also have anxioselective action.
Bibliography:Application Number: GR19880100108