BENZODIAZEPINE DERIVATIVES

PCT No. PCT/GB93/01599 Sec. 371 Date Jan. 26, 1995 Sec. 102(e) Date Jan. 26, 1995 PCT Filed Jul. 28, 1993 PCT Pub. No. WO94/03437 PCT Pub. Date Feb. 17, 1994Compounds of Formula (I), and salts and prodrugs thereof, wherein R1 represents H, optionally substituted C1-6alkyl or C3-7cycloalkyl; R2 is NH...

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Main Authors FLETCHER, STEPHEN, ROBERT 10 CLIPPED HEDGE, MOORE, KEVIN, WILLIAM 22 WHITE HART CLOSE, CARLING, WILLIAM, ROBERT 15 THE COLTS, MATASSA, VICTOR, GIULIO THE DUCK STREET BARNS, CHAMBERS, MARK, STUART 10 PARK AVENUE MAISONETTES, HOBBS, SARAH, CHRISTINE 27 GOODWIN STILE, SHOWELL, GRAHAM, ANDREW 5 BEEHIVE LANE, CASTRO PINEIRO, JOSE, LUIS, RUSSEL, MICHAEL, GEOFFREY, NEIL 11 STAPLEFORD
Format Patent
LanguageEnglish
Published 31.01.2002
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PCT No. PCT/GB93/01599 Sec. 371 Date Jan. 26, 1995 Sec. 102(e) Date Jan. 26, 1995 PCT Filed Jul. 28, 1993 PCT Pub. No. WO94/03437 PCT Pub. Date Feb. 17, 1994Compounds of Formula (I), and salts and prodrugs thereof, wherein R1 represents H, optionally substituted C1-6alkyl or C3-7cycloalkyl; R2 is NHR12 or (CH2)sR13 where 5 is 0, 1 or 2; R3 represents C1-6alkyl, halo or NR6R7; R4 and R5 are H, C1-12alkyl optionally substituted by NR9R9' or an azacyclic or azabicyclic group, optionally substituted C4-9cycloalkyl, C4-9cycloalkyl C1-4alkyl, aryl, arylC1-6alkyl or azacyclic or azabicyclic groups, or R4 and R5 together form the residue of an optionally substituted azacyclic or azabicyclic ring system; x is 0, 1, 2 or 3; R12 is optionally substituted phenyl or pyridyl; R13 represents a group (A) wherein R14 is H or C1-6alkyl; R15 is H, C1-6alkyl, halo or NR6R7; and the dotted line is an optional covalent bond; are CCK and/or gastrin antagonists useful in therapy. (I) (A)
Bibliography:Application Number: GR20010401745T