1,4-DIHYDROPYRIDINE DERIVATIVES PREPARATION METHOD

The invention is directed to processes for the preparation of dimethyl-1,4-dihydro-2,6-dimethyl-4-(2'-nitrophenyl)-pyridine-3,5-dica rboxylate by reacting 1-methoxy-1-(2'-nitrophenyl)-N-(2'-nitrophenyl)methylene methanamie or 1-(2'-nitrophenyl)-N,N'-bis-(2'-nitrophenyl)...

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Main Authors MIKITE GYULA DINNYES ILONA, NAGY KALMAN DR, LEVAI LASZLO, ZALAVARI GYORGYI, FURDYGA EVA, TOMPE PETER, MANDI ATTILA, GORGENYI FRIGYES DR, BOZSING DANIEL, IMRE JANOS, TAJTHY JUDIT EVA, BECK IVAN DR, BENKO PAL DR, SIMONYI ISTVAN, KOVANYI GYORGYI, KISS ERZSEBET, POCZIK EVA
Format Patent
LanguageEnglish
Published 23.04.1996
Edition5
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention is directed to processes for the preparation of dimethyl-1,4-dihydro-2,6-dimethyl-4-(2'-nitrophenyl)-pyridine-3,5-dica rboxylate by reacting 1-methoxy-1-(2'-nitrophenyl)-N-(2'-nitrophenyl)methylene methanamie or 1-(2'-nitrophenyl)-N,N'-bis-(2'-nitrophenyl) methylene methanediamine with methyl acetoacetate in the presence of an amine compound or by reacting the monomeric or trimeric from of 2-nitrobenzaldimine with methyl acetoacetate.
Bibliography:Application Number: GR19890100133