ANTIBODY VARIANTS

Present invention relates to the antibodies containing TNFα-binding domain and FcRn-bind site having high affinity relative to human FcRn, on pH 6, and additionally - no affinity or low affinity relative to human FcRn, on pH 7.4. Said antibodies have good pharmacokinetic features, and are used for t...

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Bibliographic Details
Main Author Furrer, Esther Maria
Format Patent
LanguageEnglish
Published 27.03.2023
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:Present invention relates to the antibodies containing TNFα-binding domain and FcRn-bind site having high affinity relative to human FcRn, on pH 6, and additionally - no affinity or low affinity relative to human FcRn, on pH 7.4. Said antibodies have good pharmacokinetic features, and are used for the treatment of inflammatory condition. s List of Sequences: 32 p.
Bibliography:Application Number: GE2018AP15316