COMBINATION THERAPY FOR HYPERPROLIFERATIVE DISEASES

Either simultaneously or sequentially adminestering (i) a therapeutically effective amount of a taxane derivative, and topotecan, a platinium coordination complex selected from the group consisting of carboplatin, tetraplatin, nucleoside analog selected from the group consisting of gemcitabine, hydr...

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Main Authors BEEBE, JEAN, SACCUZZO, JANI, JITESH, PRANLAL, HEALEY, DIANE, INGEBORG, O'LEARY, JAMES, JOHN, SCHAEFFER, TRACEY, LEE, FERRANTE, KAREN, JEAN
Format Patent
LanguageEnglish
Published 25.06.2007
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Either simultaneously or sequentially adminestering (i) a therapeutically effective amount of a taxane derivative, and topotecan, a platinium coordination complex selected from the group consisting of carboplatin, tetraplatin, nucleoside analog selected from the group consisting of gemcitabine, hydrochloride and 5-FU, an anthracycline, etoposide, teniposide, amsacrine, topoisomerase selected from the group of topotecan and Camptosar, a therapeutically effective amount of an aromatase inhibitor and (ii) compounds of formula (1) or pharmaceutically acceptable salt thereof, or prodrug and solvate (value of R1, R2, R3 and X1 are defined in the specification) for treatment of hyperproliferative diseases in mammals.
Bibliography:Application Number: GE2003AU08641