Hydroxy Pipecolate Hydroxamic Acid Derivatives as MMP Inhibitors, Pharmaceutical Compositions Containing Them and Their Use for Treatment of Diseases caused by MMP

1. Technical Result Increase in efficiency of treatment of diseases characterized by matrix metalloproteinase. 2. Essence A compounds of the formula wherein R1-R8, and Ar are defined in the description; the mentioned compounds are useful in the treatment of arthritis, cancer, and other diseases char...

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Bibliographic Details
Main Authors McClure (US), Chupak (US), Louis, Stanley, Letavic (US), Michael, Anthony, Noe (US), Mark, Carl
Format Patent
LanguageEnglish
Published 25.11.2003
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:1. Technical Result Increase in efficiency of treatment of diseases characterized by matrix metalloproteinase. 2. Essence A compounds of the formula wherein R1-R8, and Ar are defined in the description; the mentioned compounds are useful in the treatment of arthritis, cancer, and other diseases characterized by matrix metalloproteinase or mammalian reprolysin activity; pharmaceutical compositions for treatment of such diseases at which it is reasonable inhibiting of matrix metalloproteinase and mammalian reprolysin comprises as an active ingredient the mentioned compound in pharmaceutically effective amount. 3. Field of Application Medicine. Tables: 4
Bibliography:Application Number: GE1999AP05744