A genetically engineered bleb preparation for prevention or treatment of gram-negative bacterial disease

The present invention relates to an immuno-protective and non-toxic Gram-negative bleb vaccine suitable for paediatric use. Examples of the Gram-negative strains from which the blebs are made are N. meningitidis, M. catarrhalis and H. influenzae. The blebs of the invention have one or more genetic c...

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Main Authors FERON CHRISTIANE, DENOEL PHILIPPE, POOLMAN JAN, BERTHET FRANCOIS-XAVIER, DALEMANS, WILFRIED, LJ, LOBET YVES, THONNARD JOELLE, VOET PIERRE, DEQUESNE GUY, THIRY GEORGES
Format Patent
LanguageEnglish
Published 01.11.2006
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Summary:The present invention relates to an immuno-protective and non-toxic Gram-negative bleb vaccine suitable for paediatric use. Examples of the Gram-negative strains from which the blebs are made are N. meningitidis, M. catarrhalis and H. influenzae. The blebs of the invention have one or more genetic changes in the chromosome of the bacterium, including up-regulation of protective antigens, down-regulation of immunodominant non-protective antigens, and detoxification of the Lipid A moiety of LPS.
Bibliography:Application Number: GC2000P000788