Improvements in or relating to the reduction of 9(11)-dehydro-12-keto spirostanes

The invention comprises a process for the reduction of a 9(11) dehydro-12-keto-spirostane to the corresponding 12-desoxyspirostane by formation of the 12-dithioketal followed by reduction by means of an alkali metal or alkaline earth metal in liquid ammonia, a primary amine containing 1 to 5 carbon...

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Bibliographic Details
Main Authors STEPHENSON LESLIE, ELKS JOSEPH
Format Patent
LanguageEnglish
Published 04.11.1964
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
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Summary:The invention comprises a process for the reduction of a 9(11) dehydro-12-keto-spirostane to the corresponding 12-desoxyspirostane by formation of the 12-dithioketal followed by reduction by means of an alkali metal or alkaline earth metal in liquid ammonia, a primary amine containing 1 to 5 carbon atoms or a polymethylene diamine. The conversion of 9(11) dehydrohecogenin acetate to 9(11) dehydrotigogenin acetate is exemplified; the acetate group is removed during reduction and subsequent reacetylation is necessary. The Provisional Specification discloses the application of the process of the invention to 9(11) dehydro-12-keto-steroids in general. Specification 956,272 is referred to.
Bibliography:Application Number: GB19620026294