Stabilized Crispr complexes
Provided herein are polynucleotides and CRISPR effector proteins configured to be covalently bound together in a CRISPR complex. The polynucleotides can be further modified to modulate the activity of the CRISPR complex. Modification of the polynucleotide and CRISPR effector protein can be used to i...
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Main Authors | , , , , , |
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Format | Patent |
Language | English |
Published |
03.08.2022
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Subjects | |
Online Access | Get full text |
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Summary: | Provided herein are polynucleotides and CRISPR effector proteins configured to be covalently bound together in a CRISPR complex. The polynucleotides can be further modified to modulate the activity of the CRISPR complex. Modification of the polynucleotide and CRISPR effector protein can be used to improve the efficacy of target binding and/or cleavage. |
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Bibliography: | Application Number: GB202110535 |