Chemical synthesis

A method of forming a compound of formula (X), the method comprising reducing a compound of formula (VI) to give a compound of formula (IX); reacting the compound of formula (IX) with an acid of formula HA to provide the compound of formula (X): wherein R1 is -CH2Ph; R2 is selected from hydrogen, -C...

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Bibliographic Details
Main Authors Lisa Frost, Neil Barnwell, Rosaleen Joy Anderson, Matthew Levick
Format Patent
LanguageEnglish
Published 19.08.2020
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:A method of forming a compound of formula (X), the method comprising reducing a compound of formula (VI) to give a compound of formula (IX); reacting the compound of formula (IX) with an acid of formula HA to provide the compound of formula (X): wherein R1 is -CH2Ph; R2 is selected from hydrogen, -C1-4-alkyl, -C2-4-alkyenyl and C1-4-alkyl-aryl; R3 is selected from -C(O)H and -C(O)C1-4-alkyl; and A is a pharmaceutically acceptable anion is provided. A method of forming a compound of formula (X) from a compound of formula (VI) wherein R1 is tert-butyl is also disclosed. A compound of formula (VI) wherein R1 is -CH2Ph; R2 is ethyl and R3 is C(O)CH3 is also disclosed.
Bibliography:Application Number: GB20190002018