Endoluminal drug delivery device

• Main Authors: STEEN AGGERHOLM, PALLE MUNK HANSEN, SEAN E CHAMBERS
• Format: Patent
• Language: English
• Published: 17.02.2016
• Subjects: BANDAGES, DRESSINGS OR ABSORBENT PADS; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; FILTERS IMPLANTABLE INTO BLOOD VESSELS; FIRST-AID KITS; FOMENTATION; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; PROSTHESES; TREATMENT OR PROTECTION OF EYES OR EARS

A drug delivery device 10 includes expandable element 12 formed of a braided structure having a body portion 16 and first and second end cones 18, 20. The end cones are attached to a catheter assembly 14 at their necks 22, 24. The expandable element 12 can expand to a vessel contacting configuration, in which the body portion 16 contacts the vessel wall. Bioactive agent 28 covers at least the outer surface of the body portion 16 such that bioactive material can be administered to a vessel wall. The end cones 18, 20 have an open structure allowing unrestricted passage of blood through the device 10 in the deployed configuration, such that blood flow can be maintained during the administration of bioactive agent 28 from the device 10. The expandable element 12 can be radially contracted by extending the inner catheter in the longitudinal direction, both for deployment endoluminally to the treatment site and also for retrieval following the administration of the bioactive material.