Liquid ibuprofen/codeine pharmaceutical composition for oral administration, the method for preparation thereof and use thereof

• Main Authors: Femando Martinez-Alzamora Garcia, Ana Maria Jiménez Redondo, Angel Munoz Ruiz, Gonzalo Hernandez Herrero, Antonia Gomez Calvo, Nuria Sanz Menéndez
• Format: Patent
• Language: English
• Published: 07.06.2017
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a novel liquid pharmaceutical composition that contains ibuprofen in the form of a salt formed with a basic amino acid and codeine or a pharmaceutically acceptable codeine salt, for oral administration, and in particular the composition contains an ibuprofen salt or a basic amino acid such as arginine, lysine or mixtures thereof. Furthermore, the invention relates to a method for preparing said pharmaceutical composition and also the use thereof, preferably in paediatrics, for the manufacture of a drug that can be used to treat moderate-to-severe pain, inflammation, fever and/or other illnesses in which ibuprofen and/or codeine are traditionally used principally as analgesic. The composition of the invention exhibits good stability after three years under different temperature and relative humidity conditions.