A process for purifying and recycling a solvent stream

A process comprises:a) Recovering a crude recycle solvent stream comprising a tertiary formalmide (TF; e.g. DMF) and a tertiary acetamide (TA; e.g. DMAC) from a mixture comprising at least one substance less volatile than the TF and the TA;b) Reducing the concentration of TA in the crude recycle sol...

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Bibliographic Details
Main Authors JAMES EDWIN WILEY, MOHAMAD RAMI RADWAN JABER
Format Patent
LanguageEnglish
Published 29.12.2010
Subjects
APPARATUS THEREFOR
CHEMISTRY
DERIVATIVES THEREOF
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Summary:A process comprises:a) Recovering a crude recycle solvent stream comprising a tertiary formalmide (TF; e.g. DMF) and a tertiary acetamide (TA; e.g. DMAC) from a mixture comprising at least one substance less volatile than the TF and the TA;b) Reducing the concentration of TA in the crude recycle solvent stream to provide a purified recycle solvent stream (e.g. via distillation); andc) Recycling the purified recycle solvent stream for use as a reaction vehicle. Alternatively, a method comprises contacting a contaminated TF containing a TA with a chlorinating agent (e.g. N,N-dilmethylchloroformiminium chloride formed from DMF and phosgene) to react the TA with the chlorinating reagent.Alternatively, a method comprises:a) Forming a mixture of sucrose-6-acylate, reaction vehicle, TF and TA;b) Analyzing the mixture to determine the amount of TA; andc) Contacting the mixture with a quantity of chlorinating agent to react the TA and the sucrose-6-acylate with the chlorinating agent, wherein the amount of chlorinating agent is selected in accordance with the amount of TA present. The removal of DMAC from DMF may be beneficial for the production of sucralose.
Bibliography:Application Number: GB20090018699