Atrial natriuretic peptide and brain natriuretic peptide and assays and uses thereof

An in vitro method of determining activation or inactivation of the atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) hormonal systems, the method comprising detecting the presence or amount of atrial and brain natriuretic peptide prohormones (proANP and proBNP) or fragments there...

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Bibliographic Details
Main Authors OLLI VUOLTEENAHO, MINNA HIRVINEN, HEIKKI RUSKOAHO, JUHANI LEPPALUOTO, JOUKO HAAPALAHTI
Format Patent
LanguageEnglish
Published 05.01.2005
Edition7
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
TESTING
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Summary:An in vitro method of determining activation or inactivation of the atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) hormonal systems, the method comprising detecting the presence or amount of atrial and brain natriuretic peptide prohormones (proANP and proBNP) or fragments thereof in a sample. The method can be used in the diagnosis or treatment of heart failure in an individual. Also disclosed is an agent that comprises proANP, ANP or NT-proANP and proBNP, BNP, or NT-proBNP. A method of identifying a substance that binds specifically to proANP, ANP or NT-proANP and proBNP, BNP, or NT-proBNP is also disclosed.
Bibliography:Application Number: GB20030015291