Porphin & azaporphin derivatives with at least one cationic-nitrogen-containing meso-substituent for use in photodynamic therapy & in vitro sterilisation

A compound of formula I: wherein Z is CH or N; X1, X2, X3, X4, Y1, Y2, Y3 and Y4 are H or a substituent as defined on pages 4-7 of the description (where each Y group may optionally be a fused ring), and metallated forms of such compounds, e.g. having a central coordinated optionally substituted met...

Full description

Saved in:
Bibliographic Details
Main Authors DEREK EDWARD BRUNDISH, XIANG DONG FENG, WILLIAM RHYS-WILLIAMS, WILLIAM LOVE, BENOIT PUGIN
Format Patent
LanguageEnglish
Published 14.07.2004
Edition7
Subjects
Online AccessGet full text

Cover

Loading…
Abstract A compound of formula I: wherein Z is CH or N; X1, X2, X3, X4, Y1, Y2, Y3 and Y4 are H or a substituent as defined on pages 4-7 of the description (where each Y group may optionally be a fused ring), and metallated forms of such compounds, e.g. having a central coordinated optionally substituted metal or metalloid element (eg Si, Ge), are characterised in that at least one (but not all four) X group is a cationic moiety comprising a tetravalent nitrogen atom. They are photosensitive and are useful in the treatment of medical conditions for which a photodynamic compound is indicated. Pharmaceutical formulations and sterilising solutions comprising a compound of the invention are also disclosed. Such compounds may be used in photodynamictherapy to kill microorganisms (eg bacteria, mycoplasmas, yeasts, fungi and viruses) and treat infections caused by such agents.
AbstractList A compound of formula I: wherein Z is CH or N; X1, X2, X3, X4, Y1, Y2, Y3 and Y4 are H or a substituent as defined on pages 4-7 of the description (where each Y group may optionally be a fused ring), and metallated forms of such compounds, e.g. having a central coordinated optionally substituted metal or metalloid element (eg Si, Ge), are characterised in that at least one (but not all four) X group is a cationic moiety comprising a tetravalent nitrogen atom. They are photosensitive and are useful in the treatment of medical conditions for which a photodynamic compound is indicated. Pharmaceutical formulations and sterilising solutions comprising a compound of the invention are also disclosed. Such compounds may be used in photodynamictherapy to kill microorganisms (eg bacteria, mycoplasmas, yeasts, fungi and viruses) and treat infections caused by such agents.
Author WILLIAM LOVE
XIANG DONG FENG
DEREK EDWARD BRUNDISH
BENOIT PUGIN
WILLIAM RHYS-WILLIAMS
Author_xml – fullname: DEREK EDWARD BRUNDISH
– fullname: XIANG DONG FENG
– fullname: WILLIAM RHYS-WILLIAMS
– fullname: WILLIAM LOVE
– fullname: BENOIT PUGIN
BookMark eNqFjb1Ow0AQhF2QApI8A1vRWYqwlIgSUH5KivTWcl7bKzm7p9u1UfImeVsOlD7VaDQz3zwVD6JCj8X1S1PsWeAF8ILxZhpKPKHzRAY_7D2gw0BoDnkEIScqHEphT9qRlEHFkYWlgxOZljZ-m7OPJA6tJhiNIGNjr67NWfDEAbynhPGcj3My_ZHAPP8ObP_8RTFrcTBa3nRePO-2x89DSVFrsoiBhLzef7xWb5vVevNe3W_8Ap9tVJM
ContentType Patent
DBID EVB
DatabaseName esp@cenet
DatabaseTitleList
Database_xml – sequence: 1
  dbid: EVB
  name: esp@cenet
  url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP
  sourceTypes: Open Access Repository
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Chemistry
Sciences
Edition 7
ExternalDocumentID GB2397067A
GroupedDBID EVB
ID FETCH-epo_espacenet_GB2397067A3
IEDL.DBID EVB
IngestDate Fri Jul 19 15:56:07 EDT 2024
IsOpenAccess true
IsPeerReviewed false
IsScholarly false
Language English
LinkModel DirectLink
MergedId FETCHMERGED-epo_espacenet_GB2397067A3
Notes Application Number: GB20020029742
OpenAccessLink https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040714&DB=EPODOC&CC=GB&NR=2397067A
ParticipantIDs epo_espacenet_GB2397067A
PublicationCentury 2000
PublicationDate 20040714
PublicationDateYYYYMMDD 2004-07-14
PublicationDate_xml – month: 07
  year: 2004
  text: 20040714
  day: 14
PublicationDecade 2000
PublicationYear 2004
RelatedCompanies SOLVIAS AG
DESTINY PHARMA LTD
RelatedCompanies_xml – name: SOLVIAS AG
– name: DESTINY PHARMA LTD
Score 2.598723
Snippet A compound of formula I: wherein Z is CH or N; X1, X2, X3, X4, Y1, Y2, Y3 and Y4 are H or a substituent as defined on pages 4-7 of the description (where each...
SourceID epo
SourceType Open Access Repository
SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title Porphin & azaporphin derivatives with at least one cationic-nitrogen-containing meso-substituent for use in photodynamic therapy & in vitro sterilisation
URI https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040714&DB=EPODOC&locale=&CC=GB&NR=2397067A
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwdV1LT4NAEJ7UatSbVk1978Fw2xhgW9oDMQJ9xMS2MdX01kDZpiSVJYXW6D_x3zq7gHrpDVgy7E7mtcs3MwB3Ono1k3FGOW-2ZAszTn3T51QP0Zm3UCCMUKF8B83-K3uaNCYVWJS5MKpO6IcqjogaNUN9z5S9Tv4OsTyFrUzvgwgfiYfu2Pa0cncstydM8xy7Mxp6Q1dzXbvnaIMX20C_i4b5cQd2MYi2pC503hyZk5L8dyjdI9gbIa04O4YKj2tw4JZ912qw_1z87sbLQvPSE_geCeRIFBON-F9-UtyEKD8bVbo7JfJElfgZWcpuPETEnOQLiWYU1XYlUFKoBKbnLSHIO08FTdFsSKwAzoRg9ErWKSdINlmITIR5r3qSZ2h94odxZCMpEVlcIVoWQKBTuO12xm6f4hqnv-yc9pySGeYZVGOcTx0I183QN4L53GzPWMA4vtBoYyxlzS1uhFb7HOrbqFxsH7qEwxzpYlGdXUE1W635NTrxLLhR_P8Bt5-mUA
link.rule.ids 230,309,783,888,25576,76876
linkProvider European Patent Office
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwdV1LT4NAEJ7Uaqw3rZr67B4Mt40BtqU9ECPQh9pXTDW9NVC2KUkLpNAa_Sf-W2d5qJfegCXD7jCzM7v7zQzAnYxWTWWcUc7rDVHCjFNbtTmVXTTmDRQIxU1QvoN69409T2qTAizyWJgkT-hHkhwRNWqG-h4n83X4t4llJdjK6N7x8FHw0B7rlpSvjsXyhEmWobdGQ2toSqapdwxp8KoraHdxYn7cg310sDWhC613Q8SkhP8NSvsYDkZIy49PoMD9MpTMvO5aGQ772XE3XmaaF53C9yhAjng-kYj9ZYfZjYvys01Sd0dE7KgSOyZLUY2HBD4n6UC8GUW1XQcoKVQA09OSEGTFo4BGOG0IrAD2hKD3SjYRJ0g2XARx4Ka16kkaofWJH8aWraBERHIFb5kBgc6g2m6NzS7FMU5_2TntGDkz1HMo-tifChAuq66tOPO52pwxh3F8odZEX0qba1xxteYFVHZRudzdVIVSd9zvTXtPg5crOEpRLxqV2TUU4_WG36BBj53b5F_8ALLNqUM
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=Porphin+%26+azaporphin+derivatives+with+at+least+one+cationic-nitrogen-containing+meso-substituent+for+use+in+photodynamic+therapy+%26+in+vitro+sterilisation&rft.inventor=DEREK+EDWARD+BRUNDISH&rft.inventor=XIANG+DONG+FENG&rft.inventor=WILLIAM+RHYS-WILLIAMS&rft.inventor=WILLIAM+LOVE&rft.inventor=BENOIT+PUGIN&rft.date=2004-07-14&rft.externalDBID=A&rft.externalDocID=GB2397067A