Porphin & azaporphin derivatives with at least one cationic-nitrogen-containing meso-substituent for use in photodynamic therapy & in vitro sterilisation

A compound of formula I: wherein Z is CH or N; X1, X2, X3, X4, Y1, Y2, Y3 and Y4 are H or a substituent as defined on pages 4-7 of the description (where each Y group may optionally be a fused ring), and metallated forms of such compounds, e.g. having a central coordinated optionally substituted met...

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Bibliographic Details
Main Authors DEREK EDWARD BRUNDISH, XIANG DONG FENG, WILLIAM RHYS-WILLIAMS, WILLIAM LOVE, BENOIT PUGIN
Format Patent
LanguageEnglish
Published 14.07.2004
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A compound of formula I: wherein Z is CH or N; X1, X2, X3, X4, Y1, Y2, Y3 and Y4 are H or a substituent as defined on pages 4-7 of the description (where each Y group may optionally be a fused ring), and metallated forms of such compounds, e.g. having a central coordinated optionally substituted metal or metalloid element (eg Si, Ge), are characterised in that at least one (but not all four) X group is a cationic moiety comprising a tetravalent nitrogen atom. They are photosensitive and are useful in the treatment of medical conditions for which a photodynamic compound is indicated. Pharmaceutical formulations and sterilising solutions comprising a compound of the invention are also disclosed. Such compounds may be used in photodynamictherapy to kill microorganisms (eg bacteria, mycoplasmas, yeasts, fungi and viruses) and treat infections caused by such agents.
Bibliography:Application Number: GB20020029742