Organic compositions
A pharmaceutical composition suitable for forming a mucoadhesive lining in the gastrointestinal tract comprises a particular form of alginic acid or alginate salt. The acid or salt is characterised in that the mannuronic acid:glucoronic acid residue ratio (M/G) is at least unity and effective to pro...
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| Main Authors | , , , , , |
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| Format | Patent |
| Language | English |
| Published |
17.10.2001
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| Edition | 6 |
| Subjects | |
| Online Access | Get full text |
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| Abstract | A pharmaceutical composition suitable for forming a mucoadhesive lining in the gastrointestinal tract comprises a particular form of alginic acid or alginate salt. The acid or salt is characterised in that the mannuronic acid:glucoronic acid residue ratio (M/G) is at least unity and effective to provide a bioadhesive interaction with the mucosa. The composition may further comprise an alkali metal salt, a cross-linking polyvalent metal ion or a pharmaceutical active for sustained release or targeted delivery. In one embodiment the composition further comprises a low viscosity alginate and is formulated as a liquid for the treatment of reflux oesophagitis etc. |
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| AbstractList | A pharmaceutical composition suitable for forming a mucoadhesive lining in the gastrointestinal tract comprises a particular form of alginic acid or alginate salt. The acid or salt is characterised in that the mannuronic acid:glucoronic acid residue ratio (M/G) is at least unity and effective to provide a bioadhesive interaction with the mucosa. The composition may further comprise an alkali metal salt, a cross-linking polyvalent metal ion or a pharmaceutical active for sustained release or targeted delivery. In one embodiment the composition further comprises a low viscosity alginate and is formulated as a liquid for the treatment of reflux oesophagitis etc. |
| Author | DOUGLAS BANNING EDVAR JARLE ONSOYEN IAN GORDON JOLLIFFE DUNCAN QUINELL MACKENZIE CRAIG FRANK CHADWICK HAMPSON PETER WILLIAM DETTMAR |
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| RelatedCompanies | RECKITT & COLMAN PRODUCTS LIMITED |
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| Snippet | A pharmaceutical composition suitable for forming a mucoadhesive lining in the gastrointestinal tract comprises a particular form of alginic acid or alginate... |
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| SubjectTerms | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| Title | Organic compositions |
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