Organic compositions

A pharmaceutical composition suitable for forming a mucoadhesive lining in the gastrointestinal tract comprises a particular form of alginic acid or alginate salt. The acid or salt is characterised in that the mannuronic acid:glucoronic acid residue ratio (M/G) is at least unity and effective to pro...

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Main Authors IAN GORDON JOLLIFFE, FRANK CHADWICK HAMPSON, DUNCAN QUINELL MACKENZIE CRAIG, DOUGLAS BANNING, PETER WILLIAM DETTMAR, EDVAR JARLE ONSOYEN
Format Patent
LanguageEnglish
Published 17.10.2001
Edition6
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:A pharmaceutical composition suitable for forming a mucoadhesive lining in the gastrointestinal tract comprises a particular form of alginic acid or alginate salt. The acid or salt is characterised in that the mannuronic acid:glucoronic acid residue ratio (M/G) is at least unity and effective to provide a bioadhesive interaction with the mucosa. The composition may further comprise an alkali metal salt, a cross-linking polyvalent metal ion or a pharmaceutical active for sustained release or targeted delivery. In one embodiment the composition further comprises a low viscosity alginate and is formulated as a liquid for the treatment of reflux oesophagitis etc.
Bibliography:Application Number: GB19980008547