Tetramic acid derivatives

A class of 4-hydroxy-2(1H)-pyrrolone derivatives, substituted at the 3-position by an optionally substituted aryl substituent, are selective non-competitive antagonists of NMDA receptors and/or are antagonists of AMPA receptors, and are therefore of utility in the treatment of conditions, such as ne...

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Bibliographic Details
Main Authors JANUSZ J KULAGOWSKI, PAUL D LEESON, IAN M MAWER
Format Patent
LanguageEnglish
Published 17.11.1993
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:A class of 4-hydroxy-2(1H)-pyrrolone derivatives, substituted at the 3-position by an optionally substituted aryl substituent, are selective non-competitive antagonists of NMDA receptors and/or are antagonists of AMPA receptors, and are therefore of utility in the treatment of conditions, such as neurodegenerative disorders, convulsions or schizophrenia, which require the administration of an NMDA and/or AMPA receptor antagonist. The compounds have the formula: wherein R -R are hydrogen or various defined substituents.
Bibliography:Application Number: GB19930009507