ZINC COMPLEX OF 5-CHLORO-7-IODO-8HYDROXYQUINOLINE HAVING ANTIMYCOTIC ACTIVITY AND THERAPEUTIC USE THEREOF

The invention refers to a novel pharmaceutical composition having especially antimycotic activity and comprising the zinc complex of 5-chloro-7-iodo-8-hydroxyquinoline of formula (I) (I) and one or more pharmaceutically acceptable carriers. The pharmaceutical composition of the invention can be used...

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Main Authors MARTON FEKETE, ISTVAN SIMONYI, MARTA KOVACS, GIZELLA MITHOLICS, GYULA SEBESTYEN, MARIA SZELI, PAL VAGO, JANOS EGRI, ISTVAN SERES, FRIGYES GORGENYI
Format Patent
LanguageEnglish
Published 25.04.1990
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention refers to a novel pharmaceutical composition having especially antimycotic activity and comprising the zinc complex of 5-chloro-7-iodo-8-hydroxyquinoline of formula (I) (I) and one or more pharmaceutically acceptable carriers. The pharmaceutical composition of the invention can be used for the effective treatment of mycotic infections on the skin surface, mucous membranes or nails. The complex of formula (I) is prepared by reacting a solution of an alkali metal salt of 5-chloro-7-iodo-8-hydroxyquinoline with a solution containing an excess of an inorganic or organic zinc salt or a zinc complex having a lower stability constant than that of the complex of formula (I) and separating the product precipitated.
Bibliography:Application Number: GB19870009166