2H-AZETO(2,1-A -ISOQUINOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

The invention relates to new 2H-azeto[2,1-a]isoquinoline derivatives of formula (I) (I) wherein R1 and R2 represent hydroxyl or alkoxy having from 1 to 6 carbon atoms, R3 is hydroxyl, halogen or an group, wherein X is oxygen or sulfur, R4 is optionally substituted phenyl, and acid addition, metal an...

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Main Authors DR ALAJOS KALMAN, DR JENO KOBOR, DR LASZLO DENES, ELEMER EZER, DR GYORGY HAJOS, DR GABOR BERNATH, DR FERENC FULOP, DR EVA PALOSI, DR LASZLO SZPORNY, DR PAL SOHAR
Format Patent
LanguageEnglish
Published 04.09.1985
Edition4
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to new 2H-azeto[2,1-a]isoquinoline derivatives of formula (I) (I) wherein R1 and R2 represent hydroxyl or alkoxy having from 1 to 6 carbon atoms, R3 is hydroxyl, halogen or an group, wherein X is oxygen or sulfur, R4 is optionally substituted phenyl, and acid addition, metal and quaternary salts thereof. According to the invention the new compounds are prepared by cyclization of the corresponding compounds of formula (II), (II) wherein R1, R2 and R3 are as defined above, and Hal is halogen. Compounds of formula (I) are pharmaceutically active, in particular are potent analgesic and antipyretic agents.
Bibliography:Application Number: GB19840026943