1,3-7 OXAZINO4,3-A-7

The invention relates to new [1,3]oxazino[4,3-a]-isoquinoline derivatives of the formula (I) (I) wherein R1 and R2 represent hydroxyl or alkoxy having from 1 to 6 carbon atoms, R3 is hydrogen, alkyl having from 1 to 8 carbon atoms, cycloakyl or cycloalkenyl having from 3 to 6 carbon atoms, optionall...

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Main Authors DR JENO KOBOR, DR LASZLO DENES, DR PAL PERJESI, ELEMER EZER, DR GYORGY HAJOS, DR GABOR BERNATH, DR FERENC FULOP, DR EVA PALOSI, DR LASZLO SZPORNY, DR PAL SOHAR
Format Patent
LanguageEnglish
Published 05.06.1985
Edition4
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to new [1,3]oxazino[4,3-a]-isoquinoline derivatives of the formula (I) (I) wherein R1 and R2 represent hydroxyl or alkoxy having from 1 to 6 carbon atoms, R3 is hydrogen, alkyl having from 1 to 8 carbon atoms, cycloakyl or cycloalkenyl having from 3 to 6 carbon atoms, optionally substituted phenyl, aralkyl having from 1 to 4 carbon atoms in the alkyl moiety or heteroaryl, R4 is hydrogen or alkyl having from 1 to 4 carbon atoms, or R3 and R4 together form a -(CH2)n- group, in which n is an integer from 3 to 7, R5 is hydroxyl, halogen or an group, in which R6 is optionally substituted phenyl, X is oxygen or sulfur, and salts thereof. According to another aspect of the invention there is provided a process for the preparation of these compounds. Compounds of formula (I) are pharmaceutically active. Pharmaceutical compositions containing them are also within the scope of the invention.
Bibliography:Application Number: GB19840025250