BENZODIOXINOPYRROLES

Compounds are disclosed of general formula where R is H, C1-6 alkyl optionally substituted by C3-7 cycloalkyl, C3-6 alkenyl or alkynyl, C3-7 cycloalkyl, aralkyl or -CHO and the physiologically acceptable salts thereof. The compounds have selective alpha 2-adrenoreceptor antagonist action and are ind...

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Bibliographic Details
Main Authors ANDREW JAMES CRAME, ALAN DAVID BORTHWICK
Format Patent
LanguageEnglish
Published 12.02.1986
Edition4
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds are disclosed of general formula where R is H, C1-6 alkyl optionally substituted by C3-7 cycloalkyl, C3-6 alkenyl or alkynyl, C3-7 cycloalkyl, aralkyl or -CHO and the physiologically acceptable salts thereof. The compounds have selective alpha 2-adrenoreceptor antagonist action and are indicated as potentially useful for the treatment or prevention of migraine, thrombosis, diabetes, obesity, hypertension, constipation, paralytic ileus, senile dementia and analepsis, and for use in appetite suppression and for the treatment of depression; they may be formulated as pharmaceutical compositions in conventional manner. The compounds may be prepared, for example, by amination of a compound of formula where X is a leaving group such as halogen or a hydrocarbylsulphonyloxy group.
Bibliography:Application Number: GB19830028468