Naphthacenequinone synthesis

Anthracyclinones of formula (a> R1 = H, R2 = H, CH3 or alkoxy (b> R1 = OCH3 or alkoxy, R2 = R3 = H (c> R1 = R3 = H, R2 = OH or alkoxy are prepared by condensation of a quinizarin-quinone of formula R1, R2, R3 as above with 2-( alpha -hydroxyethyl)-1,3-butadiene under Diels-Alder conditions...

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Bibliographic Details
Main Authors STEFANO DEL NERO, PAOLO LOMBARDI
Format Patent
LanguageEnglish
Published 29.02.1984
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Anthracyclinones of formula (a> R1 = H, R2 = H, CH3 or alkoxy (b> R1 = OCH3 or alkoxy, R2 = R3 = H (c> R1 = R3 = H, R2 = OH or alkoxy are prepared by condensation of a quinizarin-quinone of formula R1, R2, R3 as above with 2-( alpha -hydroxyethyl)-1,3-butadiene under Diels-Alder conditions followed by manipulation of the side chains. The anthracyclinones are useful starting materials for the preparation of anti-tumour anthracycline glycosides.
Bibliography:Application Number: GB19830012928