PHOSPHORUS - CONTAINING AMIDES

Compounds of the general formula wherein X is a group R O and X is a group R O, or one of X and X is a group R and the other is hydroxy, wherein, R , R , R and R are the same or different and each represent hydrogen or a C1-4 alkyl group; Ph is a phenyl group, optionally substituted by one or more g...

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Bibliographic Details
Main Authors SAMUEL WILKINSON, GEORGE WILLIAM HARDY
Format Patent
LanguageEnglish
Published 12.06.1985
Edition4
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds of the general formula wherein X is a group R O and X is a group R O, or one of X and X is a group R and the other is hydroxy, wherein, R , R , R and R are the same or different and each represent hydrogen or a C1-4 alkyl group; Ph is a phenyl group, optionally substituted by one or more groups independently selected from halo nitro; and Y is a group of formula or a group of formula or a group of formula -NH-CH2-CO-; and basic salts thereof. These compounds have an advantageous enkephalinase inhibitory activity which renders the compounds useful in medical therapy, eg. to prolong and/or potentiate in a mammal, the effects of endogenous or exogenous enkephalins. The latter includes synthetic enkephalin analogues.
Bibliography:Application Number: GB19820027347