PROCESS FOR DE-CYANOETHYLATING BLOCKED NUCLEOTIDES

A process for selectively removing a beta -cyanoethyl blocking group from the phosphate moiety of a nucleotide or polynucleotide, which comprises treating said nucleotide or polynucleotide with a primary amine having from 3 to 5 carbon atoms or diethylamine.

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Bibliographic Details
Main Author HANSEN MAXWELL HSIUNG
Format Patent
LanguageEnglish
Published 17.04.1985
Edition4
Subjects
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Summary:A process for selectively removing a beta -cyanoethyl blocking group from the phosphate moiety of a nucleotide or polynucleotide, which comprises treating said nucleotide or polynucleotide with a primary amine having from 3 to 5 carbon atoms or diethylamine.
Bibliography:Application Number: GB19820024164