Antimicrobial preparations

Amides of general formula <FORM:1114047/C3/1> in which Z is hydrogen, halogen, or an alkyl or trifluoromethyl radical, Z1 is hydrogen, halogen or a trifluoromethyl radical and m and m1 are 1, 2 or 3, are condensed with paraformaldehyde at 90-150 DEG C. in a water-miscible organic solvent. From...

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Bibliographic Details
Main Authors LANGHEINRICH KLAUS, KLESPER HERBERT, STEINFATT FRITZ, LORENZ WALTER
Format Patent
LanguageEnglish
Published 15.05.1968
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Amides of general formula <FORM:1114047/C3/1> in which Z is hydrogen, halogen, or an alkyl or trifluoromethyl radical, Z1 is hydrogen, halogen or a trifluoromethyl radical and m and m1 are 1, 2 or 3, are condensed with paraformaldehyde at 90-150 DEG C. in a water-miscible organic solvent. From 0.3-3 moles of formaldehyde (as paraformaldehyde) may be used per mole of amide and condensation may take place in the presence of an alkali metal hydroxide. An example of a suitable amide is salicylic acid-2,3-dichloroanilide.ALSO:Solutions, e.g. in a dry cleaning solvent, of condensates of amides of general formula: <FORM:1114047/A5-A6/1> in which Z is hydrogen, halogen, or an alkali or trifluoromethyl radical, 2\sv is hydrogen, halogen or a trifluoromethyl radical and m and m\sv are 1, 2 or 3, with paraformaldehyde (see Div. C3) are useful as antimicrobial compositions. A suitable amide is salicylic acid - 2,3 - dichloroanilide. The compositions may be used in the treatment of wool, cotton, polyamide or polyacrylonitrile fabrics infected with Staphylococcus aureus, Bacterium proteus, Bacterium pyocyaneuon and Staphylococcus glycerinaceus.
Bibliography:Application Number: GB19670052891