PARTICULES LUMINESCENTES A BASE DE TERRES RARES ET LEUR UTILISATION A TITRE D'AGENT DE DIAGNOSTIC

• Main Authors: BOUZIGUES, CEDRIC, MOHAMMEDI, RABEI, PREIRA, PASCAL, RICHLY, MAXIMILIAN, GACOIN, THIERRY, ALEXANDROU, ANTIGONI
• Format: Patent
• Language: French
• Published: 23.11.2018
• Subjects: ADHESIVES; BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSESC01D OR C01F; COMPOUNDS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; DYES; ENZYMOLOGY; INORGANIC CHEMISTRY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MANUFACTURE OR TREATMENT THEREOF; MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FORELSEWHERE; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MISCELLANEOUS APPLICATIONS OF MATERIALS; MISCELLANEOUS COMPOSITIONS; MUTATION OR GENETIC ENGINEERING; NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS,MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES ASDISCRETE UNITS; NANOTECHNOLOGY; NATURAL RESINS; NON-METALLIC ELEMENTS; PAINTS; PERFORMING OPERATIONS; PHYSICS; POLISHES; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; TESTING; TRANSPORTING; VINEGAR; WINE

La présente invention concerne une particule luminescente comprenant une nanoparticule de formule A1-xLnxVO4(1-y)(PO4)y (I) dans laquelle A est choisi parmi l'yttrium (Y), le gadolinium (Gd), le lanthane (La) et leurs mélanges ; Ln est choisi parmi l'europium (Eu), le dysprosium (Dy), le samarium (Sm), le néodyme (Nd), l'erbium (Er), l'ytterbium (Yb) et leurs mélanges ; 0 < x < 1; et 0 < y < 1 ; caractérisée en ce que la nanoparticule présente en surface des cations tétraalkyl ammonium. Elle concerne également un procédé de préparation de telles particules luminescentes, une suspension colloïdale de ces particules, et leur mise en œuvre à titre d'agent de diagnostic, ainsi qu'un kit de diagnostic comprenant de telles particules luminescentes. The present invention concerns a luminescent particle comprising a nanoparticle of formulaA1-xLnxVO4(1-y)(PO4)y  (I)in which A is selected from yttrium (Y), gadolinium (Gd), lanthanum (La), and mixtures thereof; Ln is selected from europium (Eu), dysprosium (Dy), samarium (Sm), neodymium (Nd), erbium (Er), ytterbium (Yb), and mixtures thereof; 0<x<1; and 0≤y<1; characterized in that the nanoparticle on its surface has tetraalkylammonium cations in an amount such that said nanoparticle has a zeta potential, ζ, of less than or equal to −28 mV in an aqueous medium with a pH≥5, more particularly with a pH≥5.5, and with an ionic conductivity >100 μS·cm−1.It also concerns a method for preparing such luminescent particles, a colloidal suspension of these particles, and the use thereof as a diagnostic agent, and also a diagnostic kit comprising such luminescent particles.