COMPOSES THIOL ET LEUR UTILISATION POUR LA SYNTHESE D'OLIGONUCLEOTIDES MODIFIES

• Main Authors: FOURNIER-WIRTH CHANTAL, LEREAU MYRIAM, MEYER ALBERT, MAYEN JULIE, VASSEUR JEAN-JACQUES, FARRE CAROLE, MORVAN FRANCOIS, CHAIX CAROLE, CANTALOUBE JEAN-FRANCOIS
• Format: Patent
• Language: French
• Published: 11.10.2013
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; DERIVATIVES THEREOF; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; SUGARS; TESTING; VINEGAR; WINE

La présente invention concerne un composé thiol apte à former une chaîne d'oligomères pouvant être greffée sur un oligonucléotide. L'invention concerne également un oligonucléotide greffé par un tel composé, possédant ainsi une ou plusieurs fonctions thiol, apte à être immobilisé sur une surface d'or ou sur une surface greffée. The present invention relates to a thiol compound suitable for forming a chain of oligomers that can be grafted to an oligonucleotide. The invention also relates to an oligonucleotide grafted by such a compound, thus having one or more thiol functions, suitable for being immobilized on a gold surface or on a grafted surface.