PROCEDE DE PREPARATION DU SEL DE L-ARGININE DU PERINDOPRIL

Preparing perindopril L-arginine salt (I) comprises reacting perindopril and L-arginine in a solvent system comprising a binary mixture of acetonitrile and dimethyl sulfoxide, a binary mixture of ethyl acetate and dimethyl sulfoxide, and a ternary mixture of acetonitrile, dimethyl sulfoxide and tolu...

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Bibliographic Details
Main Authors LAURENT STEPHANE, GRENIER ARNAUD, MATHIEU SEBASTIEN, LINOL JULIE
Format Patent
LanguageFrench
Published 20.06.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Preparing perindopril L-arginine salt (I) comprises reacting perindopril and L-arginine in a solvent system comprising a binary mixture of acetonitrile and dimethyl sulfoxide, a binary mixture of ethyl acetate and dimethyl sulfoxide, and a ternary mixture of acetonitrile, dimethyl sulfoxide and toluene, at a temperature of 10-100[deg] C; and isolating (I) by filtration. ACTIVITY : Cardiovascular-Gen.; Hypotensive; Cardiant; Vasotropic. MECHANISM OF ACTION : Angiotensin I converting enzyme inhibitor.
Bibliography:Application Number: FR20120000034