DERIVES D'INDOLONE POUR LE TRAITEMENT DE LA MALARIA

• Main Authors: PETIT SERGE JEAN PIERRE, NALLET JEAN PIERRE, BOUAJILA JALLOUL, BOYER JEREMIE, NEPVEU FRANCOISE, KIM SOTHEA
• Format: Patent
• Language: French
• Published: 18.12.2009
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Use of indolone compounds (I) or their salts for the manufacture of a medicament to treat malaria, is claimed. Use of indolone compounds of formula (I) or their salts for the manufacture of a medicament to treat malaria, is claimed. X 1-X 4C, N or -NO; either R 11-6C alkyl (optionally substituted and unsaturated), cycloalkyl, aryl, arylalkyl or heterocycle (all optionally substituted), -CN, -COOR 3, -COR 3, -CONR 3R 4, -CF 3, -OCF 3, -OR 3, -OSO 2R 3, -SO 3H, -SO 3Na, -NO 2, -NR 3R 4, -NHCOR 3, -SR 3, -SOR 3, -SO 2R 3, -SO 2NR 3R 4, -SO 2CF 3, H or halo (which is F, Cl, Br or I); or R 1R 1cycle, which is -O(CH 2) mO-, -HN-CH=N- or -HN-CH=CH-NH-; R 3, R 41-6C alkyl (optionally unsaturated), cycloalkyl, aryl or arylalkyl (all optionally substituted) or H; and R 21-6C alkyl (optionally substituted and unsaturated), aryl or heterocycle (both optionally substituted), H, -COR 3or -COOR 3; n : 0-4; and m : 1-2. Independent claims are included for: (1) composition comprising at least (I) in association with excipients; and (2) use of (I) in association with at least another antimalarial agent for the preparation of a medicament to the treatment of malaria with a simultaneously, separately or temporarily gradual administration. [Image] ACTIVITY : Antimalarial. MECHANISM OF ACTION : None given.