DERIVES DE PER(3,6-ANHYDRO) CYCLODEXTRINES, LEUR PREPARATION ET LEUR UTILISATION POUR VEHICULER DES ELEMENTS METALLIQUES VERS DES CIBLES BIOLOGIQUES OU POUR DECONTAMINER DES CIBLES OU FLUIDES BIOLOGIQUES

• Main Authors: PERLY BRUNO, BAUDIN CECILE, DALBIEZ JEAN PIERRE
• Format: Patent
• Language: French
• Published: 11.03.2005
• Edition: 7
• Subjects: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; COMPOSITIONS BASED THEREON; DERIVATIVES THEREOF; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; POLYSACCHARIDES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR CHEMICAL WORKING-UP; THEIR RELEVANT APPARATUS; TRANSPORTING

Per(3,6-anhydro)cyclodextrin derivatives are new. Per(3,6-anhydro)cyclodextrin derivatives of formula (I) or (II) are new: [Image] R 1Q, OH, OR 3, OM, SH, SR 3, OCOR 3, NH 2, NHR 3, NR 3R 4, CONH 2, CONHR 3, CONR 3R 4, CN, COOR 3, OCH 2COOH, COOH, OSO 2R 3, N 3or R 3, at least one being Q; Q : a peptide, protein, lipid, oligonucleotide, polynucleotide, oligosaccharide, polysaccharide or biopolymer; R 3, R 4aliphatic or aromatic hydrocarbyl optionally substituted with halogen and optionally containing heteroatoms (O, S, N); M : alkali metal; R 2a bond or a spacer group; and n : 6-8. Independent claims are also included for: (1) preparing the per(3,6-anhydro)cyclodextrin derivatives; (2) metal complexes of the per(3,6-anhydro)cyclodextrin derivatives; (3) diagnostic and therapeutic compositions containing the complexes; (4) decontaminating a metal-contaminated biological medium in vitroby contacting the medium with a per(3,6-anhydro)cyclodextrin derivative as above. ACTIVITY : None given. MECHANISM OF ACTION : Radiotherapy. No biological data is given.