Acylation of aromatic compounds with benzoyl halides, useful for preparation of aromatic ketones, with indium oxide or hydroxide as recyclable catalyst

• Main Authors: DUQUENNE CHRISTOPHE, VAULTIER MICHEL, GILLET JEAN PHILIPPE
• Format: Patent
• Language: English; French
• Published: 23.07.2004
• Edition: 7
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; METALLURGY; ORGANIC CHEMISTRY; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

Method for acylation of aromatic hydrocarbons (A) with a benzoyl halide (II) to form a ketone (III) is done in presence of indium(III) oxide or hydroxide as catalyst (X), and after recovery of (III), (X) can be used in further acylations. Method for acylation of aromatic hydrocarbons (A), i.e. benzene, fused-ring aromatics, or Rn-substituted benzene, with a benzoyl halide, R2COX (II) to form a ketone of formula (III) is done in presence of indium(III) oxide or hydroxide as catalyst (X), and after recovery of (III), (X) can be used in further acylations. R = 1-10C alkyl or alkoxy, R1COO, halo, 1-3C perhaloalkyl, phenyl (optionally substituted by one or more halo), nitro, cyano, or R1OCO; R1 = 1-10C alkyl; R2 = phenyl, optionally substituted by one or more chloro, bromo, fluoro, or 1-10C alkyl; and n = 1-4. L'invention concerne un procédé d'acylation de composés aromatiques activés ou non activés qui consiste à faire réagir un composé aromatique avec un agent d'acylation en présence d'une quantité molaire d'oxyde ou d'hydroxyde d'indium au plus égale à 10 % par rapport à l'agent d'acylation.