PROCEDE DE PREPARATION DE COMPOSES ACTIFS PHARMACEUTIQUEMENT DERIVES DE BENZIMIDAZOLE

The present invention is directed to the preparation of benzimidazole derivatives of the formula (I), (I) wherein A=stands for S, SO or SO2, R1=stands for C1-4 alkyl group, R2=stands for C1-4 alkyl, C3-7 cycloalkyl or C6-10 aryl or aralkyl, comprising reacting a sulphochloride of the formula (II) (I...

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Bibliographic Details
Main Authors FERENC SPERBER, ATTILA NEMETH, CSABA HUSZAR, IREN IVANICS, EPOUSE PALI, EVA SOMFAI
Format Patent
LanguageFrench
Published 25.10.1991
Edition4
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention is directed to the preparation of benzimidazole derivatives of the formula (I), (I) wherein A=stands for S, SO or SO2, R1=stands for C1-4 alkyl group, R2=stands for C1-4 alkyl, C3-7 cycloalkyl or C6-10 aryl or aralkyl, comprising reacting a sulphochloride of the formula (II) (II) with an alkyl aluminum compound of the formula (III). Rn2AlClhd (3-n) (III) The reaction is performed in one step.
Bibliography:Application Number: FR19880010201