New substituted amides, their preparation and the medicaments which contain them

• Main Author: CLAUDE COTREL, CLAUDE GUYON, GERARD ROUSSEL ET GERARD TAURAND
• Format: Patent
• Language: English; French
• Published: 16.01.1987
• Edition: 4
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

New substituted amides of general formula (I) in which either R is 2-quinolyl, benzyl, styryl or phenyl substituted with bromine, CF3, alkyloxycarbonyl, or with chlorine in position 3, dialkylamino in position 4 or with 3 alkyloxy and R' is halogen, phenyl, phenoxy, 4-chlorophenoxy or anilino, or R is dichlorophenyl, benzoyl or anilino and R' is halogen, phenyl or anilino, or R is phenyl or alkyloxyphenyl and R' is phenyl, 4-chlorophenoxy, anilino or 1-pyrrolidinyl, the straight or branched alkyl radicals containing 1 to 4 carbon atoms, their preparation and the medicaments which contain them. The new products are useful as immunostimulating agents. NOUVEAUX AMIDES SUBSTITUES DE FORMULE GENERALE(I) DANS LAQUELLE SOIT R EST QUINOLYLE-2, BENZYLE, STYRYLE OU PHENYLE SUBSTITUE PAR BROME, CF, ALCOYLOXYCARBONYLE, OU PAR CHLORE EN POSITION-3, DIALCOYLAMINO EN POSITION-4 OU PAR 3 ALCOYLOXY ET R EST HALOGENE, PHENYLE, PHENOXY, CHLORO-4 PHENOXY OU ANILINO, SOIT R EST DICHLOROPHENYLE, BENZOYLE OU ANILINO ET R EST HALOGENE, PHENYLE OU ANILINO, SOIT R EST PHENYLE OU ALCOYLOXYPHENYLE ET R EST PHENYLE, CHLORO-4 PHENOXY, ANILINO OU PYRROLIDINYLE-1, LES RADICAUX ALCOYLE DROITS OU RAMIFIES CONTENANT 1 A 4ATOMES DE CARBONE, LEUR PREPARATION ET LES MEDICAMENTS QUI LES CONTIENNENT.LES NOUVEAUX PRODUITS SONT UTILES COMME AGENTS IMMUNOSTIMULANTS.