New substituted lysine polymers intended to serve as supports for the preparation of products for diagnosis

• Main Author: ALAIN L. DE WECK, C. H. SCHNEIDER ET H. P. ROLLI
• Format: Patent
• Language: English; French
• Published: 06.06.1986
• Edition: 4
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; TESTING; THEIR PREPARATION OR CHEMICAL WORKING-UP

New lysine polymers intended to serve as supports for the preparation of reactants for diagnostics of haptenic allergies, in which the molecules have the same number of L-lysine radicals of between 8 and 20. The lysine polymers are characterised in that, after coupling with the haptenes, they comprise hydrophilic substituents alternating with hydrophobic substituents. The hydrophilic substituents consist of carboxylatoalkyl residues such as the adipic acid residue or of oligohydroxy residues such as the gluconic acid residue. The invention also relates to products for diagnosis for cutaneous tests intended to detect haptenic allergies, consisting of the products of coupling of lysine polymers with haptens. It also relates to products for diagnosis for serological tests, consisting of a solid support on to which have been attached the products of coupling of the lysine polymers with haptens. L'INVENTION CONCERNE DE NOUVEAUX POLYMERES DE LYSINE, DESTINES A SERVIR DE SUPPORTS POUR LA PREPARATION DE REACTIFS POUR DIAGNOSTICS DES ALLERGIES HAPTENIQUES, DANS LESQUELS LES MOLECULES PRESENTENT LE MEME NOMBRE DE RADICAUX DE L-LYSINE COMPRIS ENTRE 8 ET 20.LES POLYMERES DE LYSINE SONT CARACTERISES EN CE QU'ILS COMPORTENT, APRES COUPLAGE AVEC LES HAPTENES, DES SUBSTITUANTS HYDROPHILES ALTERNANT AVEC DES SUBSTITUANTS HYDROPHOBES. LES SUBSTITUANTS HYDROPHILES SONT CONSTITUES PAR DES RESTES CARBOXYLATOALKYLE, TELS QUE LE RESTE ACIDE ADIPIQUE, OU PAR DES RESTES OLIGOHYDROXY, TELS QUE LE RESTE ACIDE GLUCONIQUE.L'INVENTION CONCERNE EGALEMENT DES PRODUITS DE DIAGNOSTIC POUR LES TESTS CUTANES DESTINES A DECELER LES ALLERGIES HAPTENIQUES, CONSTITUES PAR LES PRODUITS DE COUPLAGE DES POLYMERES DE LYSINE AVEC LES HAPTENES.ELLE CONCERNE ENCORE DES PRODUITS DE DIAGNOSTIC POUR LES TESTS SEROLOGIQUES, CONSTITUES D'UN SUPPORT SOLIDE SUR LEQUEL ONT ETE FIXES LES PRODUITS DE COUPLAGE DES POLYMERES DE LYSINE AVEC LES HAPTENES.