DERIVES DE 1-(HYDROXYMETHYL)-1,6,7,11B-TETRAHYDRO-2H,4H-(1,3)-OXAZINO- OU -THIAZINO(4,3,A)ISOQUINOLEINE, PROCEDE POUR LEUR PREPARATION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT

• Main Authors: SOHAJDA ATTILA, KOBOR JENO, FULOP FERENC, EZER ELEMER, SZPORNY LASZLO, KALMAN ALAJOS, HAJOS GYORGY, DENES LASZLO, BERNATH GABOR, GABOR BERNATH, JENO KOBOR, FERENC FULOP, ATTILA SOHAJDA, ALAJOS KALMAN, ELEMER EZER, GYORGY HAJOS, EVA PALOSI, LASZLO DENES ET LASZLO SZPORNY, PALOSI EVA
• Format: Patent
• Language: French
• Published: 27.09.1985
• Edition: 4
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

DERIVES DE 1 - (HYDROXYMETHYL) - 1,6,7,11B - TETRAHYDRO-2H,4H(1,3)OXAZINO- OU -THIAZINO(4,3-A)ISOQUINOLEINE REPRESENTES PAR LA FORMULE(I):(CF DESSIN DANS BOPI)DANS LAQUELLE: R ET R SONT DES GROUPES ALCOXY AYANT 1 A 6ATOMES DE CARBONE; X EST UN ATOME D'OXYGENE OU DE SOUFRE; Y EST O, S OU UN GROUPE NR. APPLICATION : MEDICAMENTS A ACTIVITE ANTISPASMODIQUE. The invention relates to 1-(hydroxymethyl)-1,6,7,11b-tetrahydro-2H,4H-[1,3]oxazino- or -thiazino-[4,3-a]isoquinoline derivatives of the formula (I), (I) wherein R1 and R2 are alkoxy having from 1 to 6 carbon atoms, X is oxygen or sulfur, Y is =O, =S or an =NR3 group, wherein R3 is hydrogen, alkyl having from 1 to 6 carbon atoms, cycloalkyl having from 3 to 8 carbon atoms or optionally substituted phenyl, and acid addition and quaternary salts thereof.