Vectors for expressing a antigenic rabies protein in eucaryotic cells and their application in the preparation of a vaccine

• Main Author: RICHARD LATHE, MARIE PAULE KIENY, YVES LEMOINE, GERARD LOISON, MICHEL AIGLE ET JEAN PIERRE LECOCQ
• Format: Patent
• Language: English; French
• Published: 05.04.1985
• Edition: 4
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The present invention relates to vectors for expressing a antigenic rabies protein in eucaryotic cells, characterised in that they comprise at least: - a DNA sequence 1 encoding the said antigenic rabies protein, and - elements for expressing this sequence in a eucaryotic cell. These vectors may be used for transforming eucaryotic cells so as to make them produce a antigenic rabies glycoprotein. LA PRESENTE INVENTION CONCERNE DES VECTEURS D'EXPRESSION D'UNE PROTEINE ANTIGENIQUE DE LA RAGE DANS LES CELLULES EUCARYOTES, CARACTERISES EN CE QU'ILS COMPORTENT AU MOINS:-UNE SEQUENCE D'ADN 1 CODANT POUR LADITE PROTEINE ANTIGENIQUE DE LA RAGE, ET-LES ELEMENTS D'EXPRESSION DE CETTE SEQUENCE DANS UNE CELLULE EUCARYOTE.CES VECTEURS PEUVENT ETRE UTILISES POUR TRANSFORMER DES CELLULES EUCARYOTES AFIN DE LEUR FAIRE PRODUIRE UNE GLYCOPROTEINE ANTIGENIQUE DE LA RAGE.