PROCEDE DE PREPARATION DE 1,1,1,3,3,3-HEXAFLUOROPROPANE-2-OL PAR HYDROGENOLYSE DE L'HYDRATE D'HEXAFLUOROACETONE

• Main Author: YUTAKA KATSUHARA, TOSHIHIRO NAKAMICHI, TOSHIKAZU KAWAI ET TORU NAKAZORA
• Format: Patent
• Language: French
• Published: 29.03.1985
• Edition: 4
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; APPARATUS THEREFOR; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; THEIR RELEVANT APPARATUS; TRANSPORTING

L'INVENTION CONCERNE UN PROCEDE DE PREPARATION DE 1,1,1,3,3,3,-HEXAFLUOROPROPANE-2-OL.SELON L'INVENTION, ON MET DE L'HYDROGENE GAZEUX EN CONTACT AVEC UN HYDRATE D'HEXAFLUOROACETONE EN PHASE LIQUIDE EN PRESENCE D'UN CATALYSEUR QUI EST ACTIF POUR L'HYDROGENOLYSE DE L'HYDRATE D'HEXAFLUOROACETONE EN 1,1,1,3,3,3-HEXAFLUOROPROPANE-2-OL.L'INVENTION S'APPLIQUE NOTAMMENT A LA PREPARATION D'UN SOLVANT OU D'UN INTERMEDIAIRE DE DIVERS COMPOSES COMPRENANT DES MEDICAMENTS, ANESTHESIQUES ET PRODUITS CHIMIQUES POUR L'AGRICULTURE. 1,1,1,3,3,3-hexafluoropropane-2-ol is prepared easily and efficiently by gas-liquid reaction between hydrogen gas and a hexafluoroacetone hydrate such as trihydrate, which is liquid at room temperature, using a suitable catalyst such as active carbon-palladium catalyst. Preferably the gauge pressure of hydrogen gas is 2-10 kg/cm2, and the hydrogenolysis reaction temperature is 70 DEG -100 DEG C. The life of the catalyst can be prolonged by the addition of a small quantity of sodium hydroxide. The addition of a small quantity of aluminum hydroxide is effective in suppressing the formation of fluorine ions in the reaction liquid.