PROCEDE DE PREPARATION DE L'ESTER-METHYLIQUE DE L'A-ASPARTYL PHENYLALANINE

• Main Author: MAURICE-JEAN GOURBAULT
• Format: Patent
• Language: French
• Published: 13.05.1983
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

LA PRESENTE INVENTION CONCERNE UN PROCEDE DE PREPARATION DE L'ESTER-METHYLIQUE DE L'A-ASPARTYL PHENYLALANINE PAR REACTION DE L'ESTER-METHYLIQUE DE LA PHENYLALANINE AVEC L'ANHYDRIDE DE L'ACIDE N FORMYL ASPARTIQUE PROCEDE DANS LEQUEL LE PRODUIT DE LA LADITE REACTION EST TRAITE DANS AU MOINS UNE COLONNE DANS LE MELANGE OBTENU EST ISOMERISE PAR TRAITEMENT A L'ANHYDRIDE ACETIQUE SUIVIT D'UNE HYDROLYSE ACIDE POUR TRANSFORMET LEDIT ISOMERE B EN ISOMERE A ET ASSURER LA DEFORMYLATION DE CE PRODUIT. PCT No. PCT/FR82/00181 Sec. 371 Date Jul. 5, 1983 Sec. 102(e) Date Jul. 5, 1983 PCT Filed Nov. 5, 1982 PCT Pub. No. WO83/01619 PCT Pub. Date May 11, 1983.The present invention relates to a process for the preparation of alpha -aspartyl phenylalanine methyl ester by reacting phenylalanine methyl ester with the anhydride of N-formyl L-aspartic acid, process wherein the product from said reaction is treated in at least one ion-exchanging resin column and the beta -isomer contained in the resulting mixture is isomerized by treatment with acetic anhydride followed by an acid hydrolysis to convert said beta -isomer into alpha -isomer and ensure the deformylation of said product.