PROCEDE DE PREPARATION DE NOUVEAUX COMPOSES CYTOSTATIQUES ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT

A process for the preparation of new cytostatic compounds of general formula (I> in which either R represents a beta -hydroxyl group and R represents an alpha -ethyl group or R represents a hydrogen atom and R represents a beta -ethyl group; R'' represents a methyl group, a straight cha...

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Main Author L. DANCSI, T. KEVE, G. FEKETE, E. DEZSERI, S. GOROG, T. ACS, C. SZANTAY, L. SZABO, K. HONTY, S. ECKHARDT, I. HINDI, S. KERPEL-FRONIUS, Z. RELLE NEE SOMFAI ET J. SUGAR
Format Patent
LanguageFrench
Published 04.04.1986
Edition4
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A process for the preparation of new cytostatic compounds of general formula (I> in which either R represents a beta -hydroxyl group and R represents an alpha -ethyl group or R represents a hydrogen atom and R represents a beta -ethyl group; R'' represents a methyl group, a straight chain alkyl group having from 3 to 10 carbon atoms, a branched chain alkyl group having from 3 to 10 carbon atoms and in which the carbon atom attached to the group has a primary or secondary configuration, or an aralkyl having from 1 to 3 carbon atoms in the alkyl moiety; R represents a methoxy group; and R represents an acetyl group; which comprises reacting a compound of formula (II), (in which R , R , R and R are as defined above), or an acid addition salt thereof with a large excess of an alcohol of formula R''-OH (III> (wherein R'' is as defined above) in the presence of chromium trioxide at a temperature of from -60 DEG C to -30 DEG C.
Bibliography:Application Number: FR19810015835