DERIVES DU 1,1,2-TRIPHENYLPROPANE ET DU 1,1,2-TRIPHENYLPROPENE, PROCEDE DE PREPARATION DE CES DERIVES ET COMPOSITIONS PHARMACEUTIQUES CONTENANT CES NOUVEAUX COMPOSES

• Main Author: GIZELLA ABRAHAM, TIBOR HORVATH, LAJOS TOLDY, JANOS BORVENDEG, ENDRE CSANYI, EVA KISS, ILONA SZENTE ET KALMAN TORY
• Format: Patent
• Language: French
• Published: 20.02.1981
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CHEMISTRY; FISHING; FORESTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TRAPPING

DERIVES DU 1,1,2-TRIPHENYLPROPANE OU DU 1,1,2-TRIPHENYLPROPENE SELON LA FORMULE GENERALE:(CF DESSIN DANS BOPI)OU A, B, X, Y ET R SONT TELS QUE DEFINIS DANS LA DESCRIPTION, AINSI QUE LEURS STEREOISOMERES, MELANGES D'ISOMERES ET SELS D'ADDITION AVEC DES ACIDES.PREPARATION DE TELS DERIVES A PARTIR DES SUBSTANCES DE DEPART APPROPRIEES.COMPOSITIONS PHARMACEUTIQUES CONTENANT DE TELS DERIVES. New 1,1,2-triphenylpropane and -propene derivatives of the general formula (I), wherein A and B each stand for hydrogen or they form together a valence bond, X and Y are identical or different and stand for phenyl group or a phenyl group having a halogen, hydroxy methoxymethoxy, C1-6 alkoxy or benzyloxy substituent in the para position, R1 is a C1-6 alkyl, epoxyalkyl, azidoalkyl, methoxymethyl or benzyl group or a group of the general formula (II), wherein R2 and R3 each represent hydrogen or a C1-6 alkyl, hydroxyalkyl or haloalkyl group, or R2 and R3 form together with the adjacent nitrogen atom an up to 8-membered heterocyclic group, an up to 6-membered heterocyclic group optionally containing further hetero atom(s), which heterocyclic groups optionally have a lower alkyl or hydroxyalkyl substituent, a guanidino group, an aminoguanidino group or a nitroguanidino group, with the proviso that if A and B form together a valence bond and X and Y each stand for phenyl or X is phenyl and Y is p-methoxyphenyl, R1 may not stand for a dimethylaminoethyl, diethylaminoethyl, pyrrolidinoethyl, a piperidinoethyl or morpholinoethyl group in the (Z) isomers, stereoisomers and isomeric mixtures thereof, and acid addition salts of the basic compounds of the general formula (I) exert oestrogenic or antioestrogenic effects and furthermore inhibit the growth of the mammary tumor induced by 7,12-dimethyl-benz(a)anthracene.