NOUVELLES 7A-METHOXYCEPHALOSPORINES, LEUR PROCEDE DE PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

• Main Author: ISAMU SAIKAWA, SHUNTARO TAKANO, HIROYUKI IMAIZUMI, ISAMU TAKAKURA, HIROKAZU OCHIAI, TAKASHI YASUDA, HIDEO TAKI, MASARU TAI ET YUTAKA KODAMA
• Format: Patent
• Language: French
• Published: 21.11.1980
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

A.NOUVELLES 7A-METHOXYCEPHALOSPORINES.B.ELLES REPONDENT A LA FORMULE:(CF DESSIN DANS BOPI)DANS LAQUUELLE R REPRESENTE UN ATOME D'HYDROGENE OU UN GROUPE PROTECTEUR DE CARBOXYLE; R REPRESENTE UN GROUPEMENT ORGANIQUE RELIE PAR L'INTERMEDIAIRE D'UN ATOME D'OXYGENE OU DE SOUFRE; R REPRESENTE UN GROUPE ALKYLE INFERIEUR; N EST EGAL A 0, 1 OU 2; A REPRESENTE UN GROUPE ALKYLE SUBSTITUE OU NON SUBSTITUE; R REPRESENTE UN GROUPE ALKYLE INFERIEUR; ET R REPRESENTE UN ATOME D'HYDROGENE OU UN GROUPE PROTECTEUR D'HYDROXYLE.C.MEDICAMENT. A 7???-methoxycephalosporin represented by the following general formula and a salt thereof: wherein R represents a hydrogen atom or a carboxyl-protecting group; R represents an organic group linked to the carbon atom through an oxygen or sulfur atom; R represents a lower alkyl group; n is 0, 1 or 2; A represents a substituted or unsubstituted alkyl group; R represents a lower alkyl group; and R represents a hydrogen atom or a hydroxyl-protecting group, have a broad antibacterial spectrum and high resistance to ???-lactamase produced from bacteria, and are well absorbed in a living body. They can be incorporated into pharmaceutical compositions.