NOUVELLES 7A-METHOXYCEPHALOSPORINES, LEUR PROCEDE DE PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

A.NOUVELLES 7A-METHOXYCEPHALOSPORINES.B.ELLES REPONDENT A LA FORMULE:(CF DESSIN DANS BOPI)DANS LAQUUELLE R REPRESENTE UN ATOME D'HYDROGENE OU UN GROUPE PROTECTEUR DE CARBOXYLE; R REPRESENTE UN GROUPEMENT ORGANIQUE RELIE PAR L'INTERMEDIAIRE D'UN ATOME D'OXYGENE OU DE SOUFRE; R REP...

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Main Author ISAMU SAIKAWA, SHUNTARO TAKANO, HIROYUKI IMAIZUMI, ISAMU TAKAKURA, HIROKAZU OCHIAI, TAKASHI YASUDA, HIDEO TAKI, MASARU TAI ET YUTAKA KODAMA
Format Patent
LanguageFrench
Published 21.11.1980
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:A.NOUVELLES 7A-METHOXYCEPHALOSPORINES.B.ELLES REPONDENT A LA FORMULE:(CF DESSIN DANS BOPI)DANS LAQUUELLE R REPRESENTE UN ATOME D'HYDROGENE OU UN GROUPE PROTECTEUR DE CARBOXYLE; R REPRESENTE UN GROUPEMENT ORGANIQUE RELIE PAR L'INTERMEDIAIRE D'UN ATOME D'OXYGENE OU DE SOUFRE; R REPRESENTE UN GROUPE ALKYLE INFERIEUR; N EST EGAL A 0, 1 OU 2; A REPRESENTE UN GROUPE ALKYLE SUBSTITUE OU NON SUBSTITUE; R REPRESENTE UN GROUPE ALKYLE INFERIEUR; ET R REPRESENTE UN ATOME D'HYDROGENE OU UN GROUPE PROTECTEUR D'HYDROXYLE.C.MEDICAMENT. A 7???-methoxycephalosporin represented by the following general formula and a salt thereof: wherein R represents a hydrogen atom or a carboxyl-protecting group; R represents an organic group linked to the carbon atom through an oxygen or sulfur atom; R represents a lower alkyl group; n is 0, 1 or 2; A represents a substituted or unsubstituted alkyl group; R represents a lower alkyl group; and R represents a hydrogen atom or a hydroxyl-protecting group, have a broad antibacterial spectrum and high resistance to ???-lactamase produced from bacteria, and are well absorbed in a living body. They can be incorporated into pharmaceutical compositions.
Bibliography:Application Number: FR19790024739