NOUVEAUX ANTIBIOTIQUES DE TYPE MACROLIDE, LEUR PREPARATION ET LEUR UTILISATION THERAPEUTIQUE

• Main Author: MASARU OTANI, SHUZO SATOI, NAOKI MUTO, TETSU SAITO, TADASHIRO FUJII, SEIJI KATSUMATA, MITSUO HAYASHI ET MASARU ONO
• Format: Patent
• Language: French
• Published: 07.12.1979
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; DERIVATIVES THEREOF; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; FODDER; FOODS OR FOODSTUFFS; HUMAN NECESSITIES; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; SPIRITS; SUGARS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES; VINEGAR; WINE

UN NOUVEAU MICROORGANISME APPARTENANT AU GENRE MICROMONOSPORA, MICROMONOSPORA SP. A 11725 PEUT PRODUIRE DE NOUVEAUX ANTIBIOTIQUES DE TYPE MACROLIDE A 11725 I, A 11725 II, A 11725 III. LES NOUVEAUX ANTIBIOTIQUES A 11725 IA ET A 11725 IIA SONT OBTENUS PAR MODIFICATION CHIMIQUE EN A 11725 I ET 11725 II RESPECTIVEMENT. LA FIGURE 1 DONNE LE SPECTRE IR DE A 11725 I.CES DIFFERENTS ANTIBIOTIQUES ONT UNE ACTIVITE VIS-A-VIS DE DIVERS MICROORGANISMES COMME STAPHYLOCOCCUS ET MYCOPLASMA ET SONT DONC UTILES COMME MEDICAMENTS ENTRE AUTRES. A novel microorganism species belonging to the genus Micromonospora, i.e. Micromonospora sp. A 11725 is found to be capable of producing novel macrolide antibiotics A 11725 I, A 11725 II and A 11725 III. Novel antibiotics A 11725 Ia and A 11725 IIa are also found to be derived by chemical modification of the antibiotics A 11725 I and A 11725 II, respectively. All of these antibiotics or salts thereof exhibit excellent antibacterial and anti-mycoplasmal activities against various microorganisms such as Staphylococcus or Mycoplasma, and therefore useful for various purposes including medicaments.