DERIVES DE SUBSTITUTION DE SPIROOXAZOLIDINONE STEROIDIENNE, LEUR PROCEDE DE PREPARATION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT

• Main Author: DR SANDOR SOLYOM LAJOS TOLDY, KATALIN SZILAGYI INGE SCHAFER, ELEONORA SZONDY JANOS BORVENDEG ET ILONA HERMANN
• Format: Patent
• Language: French
• Published: 26.10.1979
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; STEROIDS

Dérivés de spirooxazolidinone stéroïdienne et leur procédé de préparation. Ces dérivés correspondent à la formule générale : Diuretic pharmaceutically active steroid-spiro-oxazolidinone compounds of the formula (I), (I) wherein R1 is hydrogen or methyl, R2 is C1-4 alkyl, R3 is hydrogen, C1-4 alkyl or C2-4 alkenyl, Z1 and Z2 each are hydrogen or together form a second valence bond, or Z1 is hydrogen and Z2 is R4-S-, Z3 and Z4 each are hydrogen or together form a second valence bond, or Z3 is hydrogen and Z4 is R4-S-, with at least one of the pairs Z1-Z2 and Z3-Z4 representing hydrogen and an R4-S- group, and R4 is hydrogen or alkyl, alkenyl, aralkyl or acyl with up to 7 carbon atoms, provided that when Z1 and Z2 together form a valence bond, or Z1 represents a hydrogen atom and Z2 and R4-S- group then R1 is methyl.